RISK FACTORS FOR THE DEVELOPMENT OF PRIMARY MULTIPLE MALIGNANT TUMORS IN WOMEN (REVIEW)

Abstract

Recently, there has been an increasing interest in studying the problem of primary-multiple malignant tumors (PMMT) in oncology. Many researchers agree that PMMT are more common in women, which is associated with the increase in the incidence of hormone-dependent tumors of the reproductive system, which are represented by the mammary glands, uterus, and ovaries. The development of comprehensive examination methods, including molecular-genetic studies, contributes to the detection of synchronous PMMT of the female reproductive system. In our studies, among PMMT in breast cancer, metachronous tumors predominated (65.7%). Metachronous cancer of the uterus body (37.1% of cases) was more common than others. Determining the level of specific oncological markers helps to timely control the development of PMMT in this category of patients. Thus, each tumor of the female reproductive system should be considered as a risk marker for the development of other neoplasms, which should put the entire well-established system of dispensary accounting, observation, and the use of a full range of special methods of clarifying diagnosis in a state of rapid response.